Chloral hydrate의 단독투여와 hvdroxvzine HCℓ의 병용이 심박동과 동맥혈 산소포화도에 미치는 영향 및 진정효과에 관한 연구
COMPARISON OF CHLORAL HYDRATE WITH AND WITHOUT HYDROXYZINE HCℓ IN THE SEDATION OF PEDIATRIC DENTAL PATIENTS
박일해, 이진용,
소속 상세정보
박일해 ( ) - 경희대학교 식품공학과
이진용 ( ) - 경희대학교 치과대학 소아치과학교실
KMID : 0358919940210010159
Abstract
결 론
경희대학교 치 과대 학 부속치과병원 소아치과에 내원한 21-45개월의 환자 22명(남 10 명,
여 12명)을 대상으로 초진시 Frankl에 의한 행동분류가 negative(10명)이거나 definitely
negative(12명)이고, 2회 이상의 치과치료가 필요한 아동에게 처음 내원하였을때 무작위로
chloral hydrate(75㎎/㎏)를 단독투여 하거나 chloral hydrate(50㎎/㎏)와 hydroxyzine HCI(25
㎎)을 병용하여 경구 투여하였다. 두번째 내원시에는 다른 약제를 투여하여 진정효과를 임
상적으로 비교하고 pulse oximetry를 이용하여 치료단계에 따른 심박동 및 동맥혈 산소포화
도의 변화를 관찰하여 다음과 같은 결과를 얻었다.
1. Chloral hydrate 단독투여시는 81 8 %, hydroxyzine HCl 병용투여시는 86.3 %가 근정
효과가 나타났으나, 두 약제간의 통계학적 유의성은 없었다.
2. 부작용(구토, 오심, 설사)은 chloral hydrate 단독투여시 27 3 %, hydroxyzine HCI 병 용
투여시 9. 1%가 발생하였다.
3. 심박동은 chloral hydrate 단독투여시 국소마취 1분후, 러버댐 장착, 와동형성기에 유의
한 증가를 보였고(p<0.05), bydroxyzine HCI 병용투여시는 국소마취, 국소마취 1분후, 러버
댐 장착, 와동형성기, 치료종료후 3분에 유의한 증가를 보였다(p<0.05)
4. 동맥혈 산소포화도는 chloral hydrate 단독투여시보다 hydroxyzine HCI 병용투여시 높
았으나 통계학적 유의한 차이를 보이지 않았다.
#초록#
The purpose of this study was performed to compare the effectiveness of chloral
hydrate with and without hydroxyzine HC1 when young children were sedated for
dental treatment. As a secondary purpose was to evaluate the SaO2 and
pulse rate in patients recieving chloral hydrate with and without hydroxyzine HCI.
Twenty -two children participated in the study ranging in age from 21 to 45 months at
the Dept. of Pediatric Dentistry Kyung-Hee Medical Center. Subjects were assigned
randomly to receive either 75 ㎎/㎏ of chloral hydrate alone or 50 ㎎/㎏ together with 25
㎎ of hydroxyzine HC1 : alternative regimens were administered at two appointments.
According to rating scale, sleep, crying, movement and overall behavior were checked
for evaluation of the clinical sedative effect. Pulse rate and oxygen saturation were
Measured for safety of the patients and recorded using pulse oximetry (Nellcor N-250
Pulse oximeter/display module, U.S.A) and were evaluated the change above or below
three-minute preoperative baseline for each step.
The results were as follows :
1. The successes of sedation were 81.8 % in chloral hydrate alone and 86.3 % in
chloral hydrate with hydroxyzine HCI. There were no statistically significant differences
among the two regimens with regard to sleep, movement, crying.
2. The adverse side effects were vomiting, nausea, diarrhea in 9.1 % of the
adminstrations with hydroxyzine HCI and 27.3 % without.
3. In chloral hydrate alone, statistically significant increases of pulse rate were
observed during period of anesthetic uptake, application of rubber dam and cavity
preparation (p<0.05). In chloral hydrate with hydroxyzine HCI, statistically significant
increases of pulse rate were observed during period of injection of local anesthesia,
anesthetic uptake, application of rubber dam, cavity preparation and postoperative period
(p<0.05).
4. Oxygen saturation in chloral hydrate with hydroxyzine HCI was superior to in
chloral hydrate alone, but there were no statistically significant differences two
regimens.
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